What is the Endocannabinoid System?

The Endocannabinoid System, or ECS, was discovered in 1988 by researchers who wanted to find out where the major phytocannabinoids THC and CBD worked in the body. Because of this research, we now know that the ECS plays a role in helping to regulate sleep, mood, appetite, learning and memory, temperature control, pain control, reproduction, and inflammatory and immune responses. 

There are three components of the ECS.

1. Endocannabinoids are naturally occurring lipid-based neurotransmitters similar to cannabinoids. 

2. Receptors are formed throughout the body, mostly in the central and peripheral nervous systems. Endocannabinoids bind to these receptors and send signals to the ECS. There are currently two known types of receptors in the ECS:

    CB1 receptors exist mostly in the brain and central nervous system. They are involved in the regulation of pain, mood, sleep, appetite, and memory.

    CB2 receptors exist mostly in the immune tissues of our body and help to support the immune system.

3. Enzymes break down endocannabinoids after their work is completed. 

Both THC and CBD bind to CB1 and CB2 receptors in ECS.  CBD doesn't affect the ECS the same way THC does. It doesn't turn on CB1 receptors, it binds to them, decreasing but not abolishing the activity level of the receptor when stimulated by CB1 agonists. The effects of CBD on CB2 receptors are less understood. 

Homeostasis is a term used to describe balance and stability. It is believed that the ECS plays a major role in maintaining balance and stability in our bodies. 

With the use of cannabis, the receptors of the ECS are stimulated and therefore help to support our body's efforts to maintain homeostasis, leading to better sleep, improved mood, less pain, etc. 

For more information about the ECS system watch this: https://www.youtube.com/watch?v=IJj6Xojf4e0